阻塞性睡眠呼吸暂停综合征患者血浆血管内皮生长因子浓度测定(英文)

Increased level of vascular endothelial growth factor in obstructive sleep apnea syndrome with severe nocturnal hypoxia

目的探讨伴有不同程度夜间缺氧血症的阻塞性睡眠呼吸暂停综合征(Obstructive sleep apnea syndrome, OSAS)患者血浆血管内皮生因子(Vascular endothelial growth factor, VEGF)浓度的变化。方法40例经多导睡眠图(polysomnography, PSG)检查诊断为OSAS的患者,根据夜间缺氧程度分为2组(重度夜间缺氧组和非重度夜间缺氧组),每组各20例。清晨空腹采用检测血浆VEGF浓度。结果重度夜间缺氧组血浆VEGF浓度为(125.96±99.04)pg/ml,而非重度夜间缺氧组血浆VEGF浓度为(49.83±17.16)pg/ml,二者之间有显著差异。血浆VEGF浓度与夜间缺氧程度呈正相关(r=0.743,P<0.01)。结论重度夜间缺氧的OSAS患者血浆VEGF浓度明显升高,OSAS患者夜间缺氧的严重程度呈血浆VEGF浓度正相关。

Objective: To investigate the relationship between the level of plasma vascular endothelial growth factor (VEGF) and the severity degree of obstructive sleep apnea syndrome (OSAS). Methods: Forty patients with OSAS were evaluated by polysomnography during sleep. The concentration of plasma VEGF was measured by ELISA in samples obtained from the antecubital vein at 7 a.m. Results: Patients with severe nighttime hypoxia had significantly higher plasma VEGF levels compared with mild to moderate nighttime hypoxia ones [(154.96±99.04) pg/ml versus (49.83±17.16) pg/ml]. The degree of nocturnal oxygen desaturation in OSAS was significantly correlated with plasma VEGF level (r =0.743,P <0.01). Conclusion: The plasma level of VEGF is elevated in OSAS patients with severe hypoxia and related to the severity degree of nocturnal oxygen desaturation.