头孢曲松钠预防LC术后感染的临床研究

Clinical study of ceftriaxone sodium on prevention of postoperative infection of laparoscopic cholecystectomy

目的观察头孢曲松钠(ceftriaxone sodium)预防腹腔镜胆囊切除术(LC)后感染的临床效果。方法选择同期住院施行腹腔镜胆囊切除术的病例,随机分成试验组和对照组,试验组:术前30 min、术后1 h静脉滴注头孢曲松钠1.0～2.0 g,术后每日1次,每次1.0～2.0 g,疗程2～5 d。对照组:术前30 min、术后1 h静脉滴注罗氏芬(rocephin)1.0～2.0 g, 术后每日1次,每次1.0～2.0 g,疗程2～5 d。结果头孢曲松钠与罗氏芬在临床总有效率、细菌清除率及不良反应率等方面差异无显著性。结论头孢曲松钠能有效预防腹腔镜胆囊切除术后感染。

Objective: To evaluate the clinical effect of ceftriaxone sodium in prevention of infection after laparoscopic cholecystectomy. Methods: The patients who underwent laparoscopic cholecystectomy during the same period were elected and divided into trial group and control group randomly. Trial group: 1.0～2.0 g ceftriaxone sodium was given by intravenous drip at preoperative 30 min, postoperative 1h and once a day after operation for 2～5 days; control group: 1.0～2.0 g rocephin was given by intravenous drip at preoperative 30min,postoperative 1 h and once a day after operation for 2～5 days. Results: There was no significant difference between ceftriaxone sodium group and rocephin group in total clinical effective rate,bacterial clearance rate,occurrence rate of adverse effect and so on. Conclusions: Ceftriaxone sodium can be applied to prevent postoperative infection of laparoscopic cholecystectomy without obvious side-effects.