降钙素原在鉴别呼吸道感染时的临床意义

The Value of PCT in Differential Diagnosis of Pathogens in Respiratory Tract Infection

目的:探讨降钙素原(Procalcitonin,PCT)测定在鉴别呼吸道感染病原体中的临床作用。方法:采用免疫色谱测定法检测急性呼吸道感染患者150例(其中细菌感染70例,非细菌感染80例)及50例健康体检者的PCT和静脉血常规。结果:细菌感染组PCT为(3.45±3.21)ng/ml,WBC为(14.3±6.4)×109/L;非细菌感染组PCT为(0.67±0.57)ng/ml,WBC为(6.8±3.8)×109/L;健康体检者组PCT为(0.48±0.38)ng/ml,WBC为(7.0±3.2)×109/L,细菌感染组、非细菌感染组、健康体检者组间差异有统计学意义(P<0.01)。PCT的灵敏度、特异性、阳性预测值、阴性预测值、准确性均大于90.0%,高于WBC。结论:PCT检测是鉴别诊断细菌、非细菌感染性疾病的较好指标,在鉴别细菌性和非细菌性呼吸道感染时血清PCT优于WBC计数。快速PCT检测有助于呼吸道感染的早期鉴别诊断。

Objective: To evaluate the value of PCT in differential diagnosis of pathogens in respiratory tract infection.Methods: PCT and WBC count were tested in 150 cases with respiratory tract infection,which included 70 cases of bacterial infection(BI group) and 80 cases of nonbacterial infection(NBI group),at the same time,50 cases of healthy people were included in control group.The detection method of PCT is immunochromatografic assay.Results: BI group PCT(3.45±3.21) ng/ml,WBC(14.3±6.4) ×109 /L,NBI group PCT(0.67±0.57) ng/ml,WBC(6.8±3.8)×109 /L,control group PCT(0.48±0.38) ng/ml,WBC(7.0±3.2)×109/L.There is significant difference among the three groups statistically(P<0.01) in PCT and WBC.The value of the sensibility,specificity,positive predictive value,negative predictive value and accuracy rate is more than 90.0% in PCT,which is above that of WBC.Conclusion: PCT is a useful marker for differential diagnosis of bacterial or nonbacterial respiratory tract infection at early stage of the diseases and it is superior to WBC.