脑垂体后叶素联合催产素预防高危妊娠剖宫产术产后出血

Effect of Posterior Pituitary Hormone on Prevention of Postpartum Hemorrhage in High-risk Pregnancy after Cesarean Section

目的:探讨脑垂体后叶素对高危妊娠剖宫产术产后出血的预防效果及安全性。方法:将本院2010年10月至2011年10月收治的200例高危妊娠剖宫产产妇随机分为两组,对照组100例产妇在胎儿娩出后用20 U催产素子宫体注射;观察组100例产妇在胎儿娩出后用20 U催产素子宫体注射,再予以0.9%氯化钠溶液10 mL加脑垂体后叶素注射液12 U子宫肌壁或子宫黏膜下多点注射。观察两组产妇产后2 h、产后2～24 h的出血量、产后出血发生率、24 h Hb下降值等情况。结果:观察组的产妇产后2 h、产后2～24 h的出血量、产后出血发生率、24 h Hb下降值均明显低于对照组,差异具有统计学意义(P﹤0.05)。结论:脑垂体后叶素可明显降低产后出血率,对预防和减少产后出血的疗效确切、安全可靠。

Objective To investigate the preventive effect and safety of posterior pituitary hormone on postpartum hemorrhage in the high-risk pregnancy after cesarean section.Methods Two hundred parturients with high-risk pregnancy underwent cesarean section were randomly divided into two groups from October 2010 to October 2011 in our hospital(n=100).All parturients were injected oxytocin at a dose of 20 U into uterus,but the observation group was multi-pointed injected pituitrin at a dose of 12 U into muscle wall or submucosal of uterine in addition.The blood loss volume of 2 h and 2~24 h postoperation in observation group were compared with control group.Results The blood loss volume of 2 h and 2~24 h postoperation,incidence of postpartum hemorrhage,decrease value of Hb in 24 hours in observation group were significantly lower than those of control group(P﹤0.05).Conclusion Pituitrin can reduce incidence of postpartum hemorrhage,which is effective and reliable for preventing postpartum hemorrhage in parturients with high-risk pregnancy.