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Nrf1结构及功能研究进展 被引量：6

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摘要 NF-E2相关因子1(Nrf1)属于CNC碱性亮氨酸拉链(basic-leucine-zipper,bZIP)调节蛋白家族。研究表明Nrf1与Nrf2有相似的下游靶基因,在抗氧化应激反应中发挥重要作用。新近发现,Nrf1在细胞组织分化发育、炎症及肝脏成瘤等方面发挥重要功能。本文将近几十年来发表的以细胞或基因敲除鼠为工具的Nrf1研究内容进行综述。
作者 周淦 曹杉
机构地区 中南大学临床药理研究所遗传药理学湖南省重点实验室
出处 《生理科学进展》 CAS CSCD 北大核心 2011年第6期443-445,共3页 Progress in Physiological Sciences
关键词 抗氧化应激 Nrf1 NRF2
分类号 Q4 [生物学—生理学]
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参考文献10

  • 1Zhang Y,Crouch DH,Yamamoto M,et al.Negative regula-tion of the Nrf1 transcription factor by its N-terminal domainis independent of Keap1:Nrf1,but not Nrf2,is targeted tothe endoplasmic reticulum. Biochemical Journal . 2006
  • 2Biswas M,Chan JY.Role of Nrf1 in antioxidant response el-ement-mediated gene expression and beyond. Toxicology and Applied Pharmacology . 2010
  • 3Chen L,Kwong M,Lu R,Ginzinger D,Lee C,Leung L, et al.Nrf1 is critical for redox balance and survival of liver cells during development. Molecular and Cellular Probes . 2003
  • 4Z Xu,L Chen,L Leung,TS Yen,C Lee,JY Chan.Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proceedings of the National Academy of Sciences of the United States of America . 2005
  • 5SK Radhakrishnan,CS Lee,P Young,A Beskow,JY Chan,R Deshaies.Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. Molecular Cell . 2010
  • 6Wang W,Kwok AM,Chan JY.The p65isoform of Nrf1is a dominant negative inhibitor of ARE-mediated transcription. Journal of Biological Chemistry . 2007
  • 7Johnsen,O. et al.Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrfl with MafG: binding-site selection and regulation of transcription. Nucleic Acids Research . 1998
  • 8Kwong M,Kan YW,Chan JY.The CNC basic leucine zipper factor,Nrf1,is essential for cell survival in response to oxidative stress-in-ducing agents. Journal of Biological Chemistry . 1999
  • 9M Ohtsuji,F Katsuoka,A Kobayashi,H Aburatani,JD Hayes,M Yamamoto.Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. Journal of Biological Chemistry . 2008
  • 10Zhang, Y,J.M. Lucocq,J.D. Hayes.The Nrfl CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors. Biochemical Journal . 2009

同被引文献89

  • 1许小平,许晓巍,易克,陈莉,陈少谊,周芳,李倩玉.三氧化二砷诱导白血病细胞凋亡与核因子-κB活化的关系[J].中国实验血液学杂志,2005,13(5):764-768. 被引量：8
  • 2李玉玲,杨建业,唐俊明,潘国栋,王家宁.阿霉素诱导大鼠心衰模型不同方案的比较[J].中国比较医学杂志,2006,16(2):93-96. 被引量：59
  • 3田颖,王江,李振魁,祝善俊,聂凌,宋熔.大鼠心肌梗死后心力衰竭模型的建立和评估[J].心脏杂志,2006,18(4):404-405. 被引量：41
  • 4李光宇,赵彦艳,李英慧,王郡,刘洪,付凌雨.预适应诱发胶质瘤耐药作用机制探讨[J].中国肿瘤临床,2007,34(6):301-304. 被引量：1
  • 5IARC. IARC monographs on the evaluation of carcinogenic risks to humans[M].Lyon:IARC,2009.1-524.
  • 6Kitchin KT,Ahmad S. Oxidative stress as a possible mode of action for arsenic carcinogenesis[J].{H}Toxicology Letters,2003,(1-2):3-13.
  • 7Ren X,McHale CM,Skibola CF. An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis[J].{H}Environmental Health Perspectives,2011,(1):11-19.
  • 8Pimparkar BD,Bhave A. Arsenicosis:review of recent advances[J].{H}Journal of the Association of Physicians of India,2010.617-624,629.
  • 9Yamanaka K,Kato K,Mizoi M. The role of active arsenic species produced by metabolic reduction of dimethylarsinic acid in genotoxicityand tumorigenesis[J].{H}Toxicology and Applied Pharmacology,2004,(3):385-393.
  • 10Lau A,Villeneuve NF,Sun Z. Dual roles of Nrf2 in cancer[J].{H}PHARMACOLOGICAL RESEARCH,2008,(5-6):262-270.

引证文献6

二级引证文献24

生理科学进展
2011年 第6期

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