摘要
肾癌的发生与形成是多基因改变的复杂过程,而参与其中的机制主要有2类:①遗传学机制,即通过DNA核苷酸序列改变而形成突变,引起肿瘤形成;②表观遗传学机制,即在DNA核苷酸序列不变的情况下,通过碱基修饰而引起基因水平的变化。作为表观遗传学家族中的重要成员,DNA甲基化程度的异常变化可影响肾癌相关基因的转录,从而影响肾癌的发生。现对DNA甲基化在肾细胞癌中的早期诊断、治疗靶点、预后监测和病理分期等临床应用作一综述。
The formation of renal cell carcinoma(RCC) is a complicated process including a large number of gene modifications.There are two key mechanisms in this process: ①Genetics of RCC-mutation formation by means of DNA nucleotide sequences alteration;②Epigenetics of RCC-the levels of genes change through base modification without DNA nucleotide sequences alteration.As the major member of epigenetic family,abnormal DNA methylation can induce the RCC occurrence through influencing the transcription of RCC associated genes.Now we summarizes the roles of DNA methylation in clinical diagnosis,treatment,prognosis and pathologic staging of RCC.
出处
《医学研究生学报》
CAS
2011年第8期870-873,共4页
Journal of Medical Postgraduates
基金
辽宁省教育厅高等学校科研计划项目(2009A198)
关键词
DNA甲基化
肾细胞癌
核苷酸
DNA methylation
Renal cell carcinoma
Nucleotide
