器官保存研究进展及展望

Development and perspectives in organ preservation

维持器官保存期间移植物的活力,是器官移植成功的前提条件和根本保障。目前,单纯低温保存(cold storage,CS)仍是当前各大器官移植中心首选、最常用的保存方法。随着供体需求量的增加,越来越多的老年供体和边缘供体被用于临床,这对传统的器官保存方法提出了更高的要求。文中着重对器官保存的理论、病理生理改变以及器官保存技术等方面的最新进展进行综述。

] Maintaining organ viability after donation until transplantation is critically important for optimal graft function and survival.To date,static cold storage is the most widely used form of preservation in every day clinical practice.Although simple and effective,it is questionable whether this method is able to prevent deterioration of organ quality in the present era with increasing numbers of organs retrieved from older,more marginal,and even non-heart-beating donors.This review describes principles involved in effective preservation and focuses on some basic components and methods of organ preservation in clinical and experimental transplantation.