培化磷脂酰乙醇胺中有机溶剂残留的顶空毛细管气相色谱法测定

Determination of Residual Solvents in Phosphatidylethanolamine Pegol by Head-Space Capillary GC

建立了顶空毛细管气相色谱法测定培化磷脂酰乙醇胺中的11种残留溶剂。采用HP-FFAP毛细管柱,FID检测器,程序升温。11种溶剂在各自的浓度范围内线性关系良好。回收率为94.8%～101.6%,RSD均小于5%。

A head-space capillary GC method was established for the determination of eleven residual solvents in phosphatidylethanolamine pegol.The HP-FFAP column was used with FID detector and temperature programmed control.The calibration curves were linear in the measured concentration ranges.The recoveries were 94.8%-101.6% with RSDs less than 5%.