阿昔洛韦中有机溶剂残留的顶空气相色谱法测定

Determination of Residual Organic Solvents in Acvclovir by Headspace GC

建立了顶空气相色谱法测定阿昔洛韦中甲醇、乙醇、二氧戊环、苯和甲苯的残留量。色谱柱为DB-1毛细管柱,FID检测器。上述5种溶剂分别在5～1 000、8～1 600、0.6～120、0 15～6.0和1.42～284μg/ml浓度范围内线性关系良好。平均回收率为95.0%～100.0%,RSD为0.85%～2.75%。

A headspace GC method with FID detector was established for the determination of residual solvents-methanol, ethanol,1,3-dioxolane,benzene and toluene,in acyclovir.A DB-1 capillary column was used.The calibration curves were linear in the ranges of 5-1 000,8-1 600,0.6-120,0.15-6.0 and 1.42-284μg/ml.The average recoveries were 95%-100%,with RSDs of 0.85%-2.75%.