分泌性免疫球蛋白A与肠道黏膜免疫的关系及其分泌的营养调控

Secretory Immunoglobulin A: Relationship with Intestinal Mucosal Immunity and Nutritional Regulation of Its Secretion

分泌性免疫球蛋白A(SIgA)是由J链连接成的二聚体免疫球蛋白A(IgA)与分泌片段结合后形成的复合物。肠道内的SIgA是肠道黏膜免疫中的重要环节之一。SIgA可维持肠道黏膜内环境稳态,调控肠道内源微生态,并在黏膜上皮通过干扰病原体与上皮细胞受体结合,阻止病原体附着宿主细胞,影响病原菌毒力及免疫排异,从而阻止病原体的传播和进一步的感染,因而在免疫防御中起着非常重要的作用。营养因子(如脂肪酸、氨基酸、维生素等)在机体受到病原菌入侵或应激的情况下,可显著促进肠道SIgA的分泌,提高机体对病原菌的抵抗能力,在一定程度上改善应激动物的生产性能。

Secretory immunoglobulin A(SIgA) is composed by dimeric IgA which connected by J chain and secretory component(SC).SIgA antibodies have some important physiological functions in intestinal mucosal immunity such as maintaining stabilization of intestinal mucosal homeostasis,regulating endogenous microecology,blocking pathogen attachment to epithelial cell receptors and directly decreasing bacterial virulence and immune exclusion,thus inhibiting the spread of pathogens and further infection.Under the condition of pathogens or stress,nutritional factors such as fatty acids,amino acids and vitamins might significantly promote the secretion of intestinal SIgA,increase the body's resistance ability to pathogens,and improve the performance of the animals.