骨髓单个核细胞Coomb's试验在淋巴瘤合并贫血患者诊断中的意义

Coomb's Test,Bone Marrow Mononuclear Cells in Diagnosis of Lymphoma in Patients with Anemia

目的探讨ML(淋巴瘤)合并贫血(外周血红细胞悬液Coomb,s试验阴性)患者对骨髓的单个核细胞进行Coomb,s试验的临床价值。方法抽取我院自2008年11月至2011年11月以来,于我科治疗的血液病患者临床资料进行回顾性分析,其中A组AIHA(自身免疫性的溶血性贫血)患者10例(阳性对照组),均系外周血红细胞悬液Coomb's试验呈阳性者;B组4名正常人与46例各类型(再障,PNH,IDA等)贫血患者共50例(阴性对照组),均已明确诊断;C组ML合并贫血患者100例(实验组)均系外周血红细胞悬液Coomb,s试验呈阴性者;对3组患者骨髓的单个核细胞进行Coomb,s试验,并予以对比分析。结果对A组骨髓的单个核细胞进行Coomb,s试验,10例均提示为阳性,而B组中50例均提示为阴性,C组23例结果呈阳性,而67例结果呈阴性,A组患者骨髓单个核细胞Coomb,s试验阳性率为100.0%(10/10),C组患者阳性率为23.0%(23/100),两组差异呈显著性(P<0.05)。结论 ML合并贫血(外周血红细胞悬液Coomb,s试验阴性)患者对骨髓的单个核细胞进行Coomb,s试验检查,能够对其诊断以及鉴别诊断均提供有效的实验依据,从而避免误诊情况的发生,同时也能够对患者进行有效并且及时的治疗,应予推广。

Objective Of ML(lymphoma) with anemia in patients with bone marrow mononuclear cells(peripheral red blood cell suspension Coombs test was negative) Coomb's test of clinical value.Method Extraction in our hospital since November 2008 to November 2011,the department treatment of blood in patients with clinical data were retrospectively analyzed 10 patients of group A of AIHA(autoimmune hemolytic anemia)(positive control group),are in the peripheral blood red cell suspension Coomb's test was positive;anemia in patients of group B,four normal subjects and 46 cases of various types(aplastic anemia of PNH,the IDA,etc.) a total of 50 cases(negative control group),have a clear diagnosis;group C ML anemia in 100 patients(experimental group) are in the peripheral blood red cell suspension Coomb,s test was negative;Coomb,s test three groups of patients with bone marrow mononuclear cells,and to be the comparative analysis.Result Group A bone marrow of a single nuclear cells Coomb's test,10 cases were prompted for the positive,50 cases of group B are prompted for the negative,positive for the Group C 23 cases the results,while 67 cases results were negative group A patients with bone marrow singlenuclear cells positive Coomb,s test was 100.0%(10/10),group C patients with positive rate was 23.0%(23/100),the difference between the two groups was significant(P<0.05).Conclusion ML with anemia(peripheral red blood cell suspension Coombs test was negative) patients with bone marrow mononuclear cells of a Coomb's test to check to its diagnosis and differential diagnosis provides a valid experimental basis,in order to avoid the occurrence of misdiagnosis,but also be able topatients with effective and timely treatment,should be promoted.