5-甲基-4-乙酰基-1-对氯苄基-1,2,3-三唑的合成研究

Synthesis of 1-(4-Chlorobenzyl)-4-acetyl-5-methyl-1,2,3-triazole

以对氯苄基叠氮和乙酰丙酮为原料合成5-甲基-4-乙酰基-1-对氯苄基-1,2,3-三唑,考察了催化剂类型、溶剂、配比对反应的影响,并确定了优化的工艺条件:无水碳酸钾为催化剂,乙腈和乙醇等体积混合为反应溶剂,n(对氯苄基叠氮)∶n(乙酰丙酮)=1∶1.2,反应时间2 h。产品收率达94%,目标化合物的结构经1H NMR和IR确证。

1-(4-Chlorobenzyl)-4-acetyl-5-methyl-1,2,3-triazole was synthesized from 1-(azidomethyl)-4-chlorobenzene and acetylacetone.Best results with 94% yield were obtained under conditions of catalyst of anhydrous potassium carbonate,reaction dissolvent of acetonitrile and ethanol(1∶1),molar ratio of 1-(azidomethyl)-4-chlorobenzene to acetylacetone of 1 to 1.2 and reaction time of 2 h.The structure of the title compound was confirmed by 1H NMR and IR.