氟达拉滨联合环磷酰胺治疗慢性淋巴细胞白血病疗效分析

Treatment of Chronic Lymphocytic Leukemia with FC Regimen

目的:为探讨氟达拉滨联合环磷酰胺治疗慢性淋巴细胞白血病疗效,采用FC方案(4～6个疗程)治疗9例CLL患者,其中3初治、6复治。FCR方案包括氟达拉滨25mg/m2d1-3,环磷酰胺250mg/m2d1-3,每28天一个疗程。采用流式细胞术(FCM)检测CLL细胞数。结果:7例达完全缓解(CR),2例部分缓解(PR),2例MRD为阴性。FC方案的毒副作用主要表现为骨髓抑制和胃肠道反应。结论:FC方案对CLL的治疗有确切疗效,远期疗效需进一步观察和探讨。

Objective:In order to evaluate the effect of fludarabine and cyclophosphamide(FC) regimen for chronic lymphocytic leukemia(CLL).Nine patients with CLL were treated with FC regimen for 4 ～ 6 courses.FC regimen included fludarabine 25mg/m2 d1-3,cyclophosphamide 250mg/m2 d1 3.Courses were repeated every 4 weeks.Minimal residual disease was determined by multiparametic flow cytometry.The results showed that 7 patiens achieved complete remission,2 patiens achieved partial remission.MRD was negative in two patiens.In conclusion,FC regimen is an effective therapeutic option for CLL patients and deserved further application.