乳酪乳清对大鼠离体胸主动脉环的舒张作用

Vasorelaxant Effect of Traditional Fermented Cheese Whey on Isolated Rat Thoracic Aortic Rings

采用大鼠离体胸主动脉灌流技术,观察新疆哈萨克传统发酵乳酪的乳清(TFCW)对大鼠离体胸主动脉环的作用,确定其是否对血管具有舒张作用。结果表明,TFCW对主动脉环的基础张力没有明显影响且不影响平滑肌细胞外钙内流,对去氧肾上腺素(PE)10μmol/L预收缩的血管环有明显舒张作用。TFCW可能通过多靶点扩张血管。

Through many years’ efforts,we have demonstrated that traditional fermented cheese whey(TFCW),a traditional Kazakh medicine,is effective against atherosclerosis.In the present study,the effect of TFCW on isolated rat thoracic aortic rings was observed using Langendorff perfusion technique to determine whether TFCW has vasorelaxant functions.TFCW had no notable effect on fundamental tension in thoracic aortic rings and did not affect extracellular calcium influx in vascular smooth muscle(VSM) cells but showed a remarkable vasorelaxant effect on pre-contraction induced by 10 μmol/L phenylephrine(PE) in thoracic arterial rings probably through a multi-target mechanism.