铁蛋白与进展性卒中关系的研究

Research on the Correlation between Serum Ferritin and Progressive Ischemic Stroke

目的研究铁蛋白与进展性卒中的关系及铁蛋白在进展性缺血性卒中发病机制中的作用,为进展性卒中的治疗和判断预后提供实验依据.方法采用德国贝尔公司生产的全自动发光仪测定150例(其中,进展性卒中患者50例,非进展性卒中患者50例,无梗死患者50例)患者入院第1,4,7天铁蛋白水平,同时记录患者的性别、年龄及入院时的神经功能缺失评分.结果同一天铁蛋白水平进展性卒中组比非进展性卒中组、对照组均高(P<0.01),进展性卒中组、非进展性卒中组两组组内比较,第4天铁蛋白水平高于第1,7天(P<0.01);铁蛋白与神经功能缺失症状的轻重呈直线相关(女性P<0.05;男性P<0.01).结论铁蛋白水平越高,卒中进展的可能性越大,可以作为缺血性脑卒中进展的预测因子.

Objective To explore the relationship between serum ferritin and progressive ischemic stroke and the role of ferritin in the pathogenesis of progressive ischemic stroke so as to provide an evidence for the treatment and prognosis of progressive ischemic stroke.Method Serum ferritin contents of 150 patients with progressive ischemic stroke(including 50 cases of progressive ischemic stroke,50 cases of non-progressive stroke and 50 cases of non-infarction)were detected by the auto lamination meter made in Germany on day 1,4 and 7 after the admission respectively.And at the same time,their sexes,ages and neurological deficits scores were recorded.Results Values of serum ferritin of patients in the progressive ischemic stroke group were higher on the same day compared with those in the non-progressive stroke group and the control group(P<0.01).Values of serum ferritin of patients in the progressive ischemic stroke group and non-progressive stroke group on the 4th were higher than those on the first day and the 7th day(P<0.01);The level of serum ferritin directly correlated with the severity of symptom of the neurological functional deficits(female P<0.05;male P<0.01).Conclusion The serum ferritin content is higher,the more possible the development of stroke should be,which can be taken as a prognostic factor for progressive ischemic stroke.