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基质金属蛋白酶及其抑制剂与糖尿病肾病的关系 被引量：2

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摘要 糖尿病肾病(DN)是引起终末期肾病最主要原因之一.但引起DN发生及发展的具体机制至今仍不完全明确.DN的早期病理改变是系膜区扩张,主要是由于细胞外基质(ECM)沉积和系膜细胞增生所致;肾小球基底膜(GBM)增厚也在早期可见,主要是由于ECM代谢失衡.由于在正常肾脏ECM重构中系膜细胞产生的基质金属蛋白酶(MMPs)负责了70%的ECM代谢,因此认为DN的发生发展与肾内MMPs的代谢失调密切相关.
作者 王广利 杨毅华
机构地区 汕头大学医学院第二附属医院内分泌代谢科
出处 《中华临床医师杂志（电子版）》 CAS 2012年第21期6862-6864,共3页 Chinese Journal of Clinicians(Electronic Edition)
关键词 糖尿病肾病 基质金属蛋白酶 系膜细胞增生 早期病理改变 系膜区 终末期肾病 肾小球基底膜 细胞外基质 糖基化终产物 肾病进展
分类号 R587.2 [医药卫生—内分泌] R692.9 [医药卫生—泌尿科学]
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共引文献29

同被引文献19

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二级引证文献25

中华临床医师杂志（电子版）
2012年 第21期

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