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4-氟-1,2-苯二胺的合成 被引量：2

Synthesis of 4-Fluorobenzene-1,2-diamine
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摘要 以4-氟苯胺为起始原料,先用一锅法将氨基进行保护并进行硝化,再用9 mol/L盐酸去乙酰化保护后,选用Raney镍还原制得4-氟-1,2-苯二胺。总收率为68.6%,产品经1H NMR和MS表征。本合成工艺提高了反应收率,降低了生产成本,增加了反应的稳定性,有利于工业化生产。 4-Fluorobenzene-1,2-diamine was synthesized via three steps in an overall yield of 68.6% using 4fluoroaniline as the starting material.The structure of the product was identified with 1H NMR and MS.This new process is more suitable for industrial production because of its higher yield,lower cost and higher stability.
作者 王永珍 钱鹏宇 徐明 李艳阳 谢宁 赵砚瑾 李庶心
机构地区 中南大学药学院 军事医学科学院放射与辐射医学研究所 江西中医学院
出处 《精细化工中间体》 CAS 2012年第6期26-27,52,共3页 Fine Chemical Intermediates
基金 国家科技重大专项(2012ZX09102101-013) 国家自然科学基金资助项目(30772628)
关键词 4-氟-1 2-苯二胺 4-氟苯胺 RANEY Ni还原 合成 4-fluorobenzene-1,2-diamine 4-fluoroaniline Raney Ni reduction synthesis
分类号 TQ246.2 [化学工程—有机化工]
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参考文献8

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共引文献8

同被引文献20

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精细化工中间体
2012年 第6期

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