摘要
1-芳基-2-吡咯烷酮衍生物是重要的有机合成中间体。以苯佐卡因为原料,经溴代、缩合、环合合成了目标产物,产物总收率达72.25%。其结构经1H NMR,MS进行了确证。该方法具有操作简便、成本低、收率高等优点。
1-Aryl-2-pyrrolidinone derivatives are important intermediates for organic synthesis.A novel process was developed for the synthesis of the title compound in an overall yield of 72.2% starting from benzocaine via bromination,nucleophilic substitution and cyclization.The structure of the target compound was confirmed with 1H NMR and MS.This method shows advantages of easy operation,low cost and high yield.
出处
《精细化工中间体》
CAS
2012年第6期39-41,44,共4页
Fine Chemical Intermediates
