多晶型药物研发及制剂最新研究进展

目前多晶型药物研究日益受到医药研发与质量管理领域的重视。本文首先对药物多晶型的形成、分类及其对药物药效的影响进行阐述,表明药物晶型研究的重要性。然后从实际药物多晶型制剂生产方面,讨论晶型药物研制放大的方法及制剂工艺可能对晶型药物造成的影响。最后概述了多晶型药物的检测方法。

Recently,the drug polymorphism research is strongly emphasized in the field of phamaceutical R&D and quality management.This article described the formation、classification and pharmacodynamics of drug polymorphisms first.And then this article discuss about the preparation of the crystalline drug and its scale-up.At last,the dection of drug polymorphs were involved.