来航鸡FOXL2蛋白的生物信息学分析

Bioinformatic of FOXL2 Protein from Leghorn Chicken

目的:预测来航鸡FOXL2蛋白的结构和功能。方法:生物信息学方法预测来航鸡FOXL2蛋白的组成,基本性质、同时构建其编码产物的系统进化树,并对其抗原表位进行预测。结果:该条氨基酸残基中脯氨酸含量最多,分子量为33 504.8,半衰期为30h,理论等电点为9.04,分子式为C1488H2269N425O432S15,在细胞核内发挥作用,可能具有转录和转录调控功能,与红原鸡的同源性最高,其最有可能的抗原表位位于37-49、82-91、133-147个氨基酸之间。结论:利用生物信息学方法预测其功能和结构,为对其下一步研究奠定基础。

Objective:To obtain more information about FOXL2 protein from Leghorn chicken.Method:Bioinformatics approach were applied to analyze FOXL2 protein's structures,composition,functions,physical and chemical properties,multiple sequence alignment with its homologous sequences,B-cell epitopes.Result:It was found that the highest content of amino acid was Pro,the molecular mass is 33504.8,the half-life is 30h,the theoreticaI isoelectric is 9.04,maybe play a role in the cell nucleus,the most likely function of this protein was transcription and transcription regulation,has the highest homology with Gallus gallus,the most likely epitope is 37-49,82-91,133-147.Conclusion:We obtained more biological information about FOXL2 protein by bioinformatic analysis,which is very useful for further research.