利多卡因在搭桥术中抑制再灌注室颤研究

Study of Lidocaine on Prevention of Reperfusion Ventricular Fibrillation after Release of Aortic Cross-clamping Undergoing CABG

目的 研究冠脉搭桥手术中 ,开放升主动脉时注入 1 0 0mg利多卡因是否有利于避免再灌注室颤。方法 将 30例CAD患者随机分成 2组 :利多卡因组 (L组 )和对照组 (C组 )。L组 1 5名患者于升主动脉开放前 1分钟给予 1 0 0mg利多卡因 ,对照组给予 5ml的生理盐水 ,通过swan—ganz导管监测全组病人麻醉诱导后以及脱离体外循环后的血流动力学指标。结果 ①L组的再灌注室颤的发生率 (1 7% )明显低于对照组 (5 8% )。 (P〈0 .0 5 )。②两组患者应用血管活性药物 ,没有明显差异。③与对照组比较利多卡因在脱离体外循环后心排量明显增加。 (P〈0 .0 1 )。

Objective To investigate whether to infuse the bolus 100mg lidocaine clamping in inhibiting the occurrence of reperfusion ventricular fibrillation during CABG .Methods 30 CAD patients were randomly divided into two groups :Group of lidocaine(Group L, n=15);Group of control (Group C, n=15). 15 patients in group L receive 100mg lidocaine 1 minute before release of the ACC and 15 patients in group C received 5ml saline .Blood dynamic indexes were monitored by the swan-ganz before induced and after weaning from cardiopulmonary bypass .Results ①The rate (17%) of rebeating in group L is higher than that of group C (P<0.05) .②There is no differences in drugs after operation .③Compared with the group C, the CO of group L is much higher (P<0.01).Conclusion A bolus of lidocaine infused by way of the bypass of oxygenator can decrease the incidence of reperfusion ventricular fibrillation.