不同煎煮方式对芍药甘草复方大鼠血中移行组分的药动学影响

Pharmacokinetics effect of Shaoyao Gancao compound with different decocting methods on characteristic ingredients in rat plasma after oral administration

目的:探讨不同煎煮方式对芍药甘草复方大鼠血中移行组分的药动学影响,从药动学角度阐释芍药甘草复方相使配伍的合理性。方法:在建立芍药甘草体内成分指纹图谱分析方法的基础上,运用药动学方法比较灌胃给药后不同时间的大鼠血浆中各药味特征移行入血成分含量的变化,并对药动学参数进行方差分析。结果:移行入血的6个成分在体内的吸收趋势均为芍药甘草合煎液大于单煎合并液,其中保留时间为5.2,11.0,12.0,14.6 min处的特征峰具有统计学意义。结论:芍药甘草复方相使配伍在体内吸收以合煎较好,从药动学角度证明了芍药甘草复方相使配伍的合理性。

Objective: To observe the pharmacokinetic effect of Shaoyao Gancao compound on rats using different decocting methods,and to pharmacokinetically detect the the compatibility of the component compounds of the Shaoyao Gancao compound from the pharmacokinetic viewpoint.Method: Based on the established HPLC analytical method of plasma effective constituents,rats were orally administered with a single or mixed decoction of Shaoyao and Gancao.Blood at different times after administering these decoctions were collected,and then variance analysis was made for pharmacokinetic parameters.Result: The results of all six rats indicated that the absorption of the mixed decoction of Shaoyao and Gancao was greater than that of the single decoction.While,the absorption of the characteristic peaks at the retention time of 5.2,11.0,12.0,14.6 min had statistical significance.Conclusion: Shaoyao Gancao compound was proved better than that of the single decoction from the pharmacokinetic viewpoint.