摘要
目的:更全面地阐明中药连翘的活性物质基础。方法:利用多种色谱方法分离连翘Forsythia suspensa果实的化学成分,并通过ESI-MS/MS及1D-和2D-NMR等波谱方法鉴定出24种化合物,它们的结构类型分别属于木脂素、黄酮、环己乙醇衍生物、三萜和神经酰胺。结果和结论:发现化合物1~10为首次从中药连翘果实中分离得到的神经酰胺类化合物,其中1,2,4,5的结构为首次报道。
Twenty-four compounds in the fruits of Forsythia suspensa were isolated and purified by column chromatography and preparative TLC.On the basis of comprehensive spectroscopic methods including IR,ESI-MS/MS,1D and 2D NMR,these compounds were identified as ten ceremides(1-10),six triterpenes(11-16),one steroids(17),three flavonoids(18-20),two C6-C2 alcohols(21-22)and two lignans(23-24).Compounds 1-10 were reported from F.suspense for the first time,among which 1,2,4 and 5 were new ones.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2012年第1期57-60,共4页
China Journal of Chinese Materia Medica
基金
国家"重大新药创制"科技重大专项(2009ZX09103-439)
国家重点基础研究发展计划(973)项目(2007CB512604)
关键词
连翘
神经酰胺
分离鉴定
Forsythia suspensa
ceremide
isolation and identification