方剂配伍减毒的现代研究进展

Advance of research on toxic attenuation by compatibility of traditional Chinese medicine prescriptions

中草药在中国的使用已经有几千年的历史,其疗效也已经得到了广泛的临床验证。方剂配伍是中药临床应用的基本原则,通过合理配伍达到增效减毒的目的,是中药安全、有效使用的主要方法,然而其机制并不明确。因此,采用现代药理研究的技术,对中药配伍减毒机制进行深入研究是十分必要的。目前,关于中药配伍减毒的机制研究主要包括降低体内毒性药物浓度,改变毒性药物体内药代动力学参数及保护人体各系统功能等方面。作者拟对方剂配伍减毒机制的相关研究进行探讨。

The Chinese herbs have been used for thousands years,their effects were certified in clinic.The compatibility of Chinese medicine prescriptions is the basis principle in clinical application.In order to enhance efficacy and reduce toxicity,reasonable compatibility of the Chinese herbs is the main method for the safety and effective use.However,it is not clear about its mechanism.So it is necessary to study their mechanisms by using the modern pharmacological technology.At present,there are some studies on the mechanisms of the compatibility relating with toxicity or adverse effect attenuation,for instance,reducing the dose of toxic Chinese herbs,changing their pharmacokinetic parameter and resisting the damage to human body system.In this paper,we planed to review the attenuation mechanism of the prescription compatibility from relevant studies.