期刊文献+

达方吡啶改善多发性硬化相关的行走障碍

原文传递
导出
摘要 多发性硬化(multiple sclerosis,MS)是一种中枢神经系统(central nervous system,CNS)的炎性脱髓鞘性疾病,病理学特征包括血管周围炎性细胞浸润、脱髓鞘、轴索丢失和少突胶质细胞损害等.临床可表现为视觉缺失或复视、肌力减弱、感觉异常或缺失等[1] .其中行走障碍限制患者参与各种活动,是MS 最令人恐惧和致残的症状之一[2] .
出处 《中华脑科疾病与康复杂志(电子版)》 2012年第2期129-131,共3页 Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition)
  • 相关文献

参考文献24

  • 1Compston A,Cole A. Mutiple Sclerosis[J].The Lancet,2008,(9648):1502-1517.
  • 2Dunn J. Impact of mobility impairment on the burden of caregiving in individuals with multiple sclerosis[J].Expert Rev Pharmacoecon Outcomes Res,2010,(04):433-440.
  • 3Shi R,Blight AR. Differential effects of low and high concentrations of 4-aminopyridine on axonal conduction in normal and injured spinal cord[J].Neuroscience,1997,(02):553-562.
  • 4Wu ZZ,Chen SR,Pan HL. Aminopyridines potentiate synaptic and neuromuscular transmission by targeting the voltage-activated calcium channel beta subunit[J].Journal of Biological Chemistry,2009,(52):36453-36461.
  • 5Smith W,Swan S,Marbury T. Single-dose pharmacokinetics of sustained-release fampridine (fampridine-SR) in healthy volunteers and adults with renal impairment[J].Journal of Clinical Pharmacology,2010,(02):151-159.
  • 6Henney HR 3rd,Faust B,Blight AR. Effect of food on the single-dose pharmacokinetics and tolerability of dalfampridine extended-release tablets in healthy volunteers[J].American Journal of Health-System Pharmacy,2011,(22):2148-2154.
  • 7Vollmer T,Blight AR,Henney HR 3rd. Steady-state pharmacokinetics and tolerability of orally administered fampridine sustained-release 10-mg tablets in patients with multiple sclerosis:a 2-week,open-label,follow-up study[J].Clinical Therapeutics,2009,(10):2215-2223.
  • 8Blight AR,Henney HR. Pharmacokinetics of 14 C-radioactivity after oral intake of a single dose of 14C-labeled fampridine (4-aminopyridine)in healthy volunteers[J].Clinical Therapeutics,2009,(02):328-335.
  • 9Judge SI,Lee JM,Bever CT Jr. Voltage-gated potassium channels in multiple sclerosis:Overview and new implications for treatment of central nervous system inflammation and degeneration[J].Journal of Rehabilitation Research and Development,2006,(01):111-122.
  • 10Hersh C,Rae-Grant A. Extended-release dalfampridine in the management of multiple-sclerosis-related walking impairment[J].Ther Adv Neurol Disord,2012,(04):199-204.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部