非糖尿病代谢综合征患者血清脂联素水平与胰岛素抵抗的相关性的研究

The relationship between serum adiponectin levels and Insulin resistance in metabolic syndrome patients Without diabetes

目的研究非糖尿病代谢综合征患者血清脂联素水平的变化,分析其与胰岛素抵抗的相关性。方法选择非糖尿病代谢综合征患者92例(A组),健康对照组30例(B组),应用酶联免疫吸附法测定所有受试者血清脂联素水平,分析两组脂联素水平的变化,同时计算其胰岛素敏感指数及胰岛素抵抗指数,并分析其与脂联素的相关性。结果 (1)非糖尿病代谢综合征组血清脂联素水平明显低于健康对照组(分别为1.15±0.81mg/l,4.81±1.20 mg/l,P<0.01)。(2)经直线相关分析显示,非糖尿病代谢综合征组患者血清脂联素水平与胰岛素抵抗指数呈负相关(P<0.01),与胰岛素敏感指数呈正相关(P<0.01)。结论非糖尿病代谢综合征患者血清脂联素水平明显降低,血清脂联素水平与胰岛素抵抗指数呈显著负相关,提示血清脂联素水平与代谢综合征和胰岛素抵抗的发生发展相关。

Objective To investigate serum adiponectin levels in metabolic syndrome patients without diabetes and to analyse the relationship between serum adiponectin levels,and Insulin resistance(IR).Methods 92 metabolic syndrome patients without diabetes and 30 health persons were investigated. Serum adiponectin levels of all subjects were determined by using enzyme linked immunosorbent assay(ELISA).Homeostasis insulin resistance index (Homa-IR) and insulin sensitivity index(ISI) were calculated.And then,the relationship between serum adiponectin levels and Insulin resistance(IR) wil be analysed.Results 1.The serum level of adiponectin was significantly lower in metabolic syndrome without diabetes group than in normal control group (1.15±0.81mg/l,4.81±1.20 mg/1,P<0.01 =).2.The serum adiponectin level was negatively correlated with Homa-IR(P<0.01).and positively correlated with ISI through linear correlation analysis(P<0.01).However,the serum adiponectin level was only negatively correlated with Homa-IR through multiple linear regression analysis.Conclusions The level of serum adiponectin in metabolic syndrome cases without diabetes was significantly decreased.The serum adiponectin level was negatively correlated with Homa-IR.This shows that level of serum adiponectin was correlated with metabolic syndrome and insulin resistance.