雷尼镍催化加氢制备3,4-二甲基苯胺

Preparation of 3,4-dimethylaniline by Raney nickel catalyst

以3,4-二甲基硝基苯为原料,在雷尼镍催化剂作用下催化加氢制备3,4-二甲基苯胺,通过气相色谱分析3,4-二甲基苯胺的纯度。考察加氢压力、加氢溶剂、加氢温度、底物浓度、催化剂用量等因素对加氢反应的影响。结果表明,以乙醇为加氢溶剂,加氢压力0.8 MPa、温度60℃、3,4-二甲基硝基苯初始浓度1.25mol/L、催化剂质量为3,4-二甲基硝基苯质量的5%时,3,4-二甲基硝基苯转化率和3,4-二甲基苯胺收率和3,4-二甲基苯胺纯度均达100%。

3,4-dimethylaniline was prepared by catalytic hydrogenation with Raney nickel catalyst using 3,4-dimethylnitrobenzene as staring substrate.Effects of hydrogenation have been investigated in the optimized conditions: w(catalyst/substrate)=5% in ethanol,initial concentration of the substrate=1.25 mol/L,60 ℃ and 0.8 MPa.Both reactant conversion and the purity of 3,4-dimethylaniline can be up to 100%.