ε-己内酯的合成研究

Study on the synthesis of chemical intermediates ε-caprolactone

采用煅烧法、共沉淀法制备出一系列金属氧化物催化剂,对比了不同制备条件的催化剂在双氧水氧化环己酮的合成ε-己内酯的应用,并探讨了该反应的可能反应机理。结果表明,以乙腈为溶剂,煅烧法制备的MgO对合成ε-己内酯表现出较高的催化活性;在n(H2O2):n(MgO):n(环己酮)为8:0.65:1,72℃下反应6h,环己酮的转化率为92.97%,ε-己内酯的选择性为80.94%。

We synthesized a series of oxides and used them as a catalysts in the Baeyer Villiger (BV) oxidation of cyclohexanone with a mixture of 30% aqueous hydrogen peroxide and acetonitrile as oxidant. The magnesium oxide obtained by calcined from the nitrate was found to be the best catalyst, providing the highest conversion to e-caprolactone and initial catalytic activity among all catalysts we studied. Then we examined the influence of the variables involved in the process in depth in order to bring the operating conditions as close as possible to the usable on an industrial scale.The results show that, when using acetonitrile as solvent, MgO as catalyst for Baeyer-Villiger oxidation cyclohexanone synthesis caprolactone have a higher catalytic activity, conversion was 92.97% of cyclohexanone, the selectivity of the catalyst was 80.94%.