成人过敏性难治性支气管哮喘患者血清维生素D水平的相关临床研究

Clinical study of serum vitamin D levels in adult with severe allergic bronchial asthma

目的研究成人难治性过敏性支气管哮喘(简称哮喘)患者血清维生素D水平以及和肺功能、总免疫球蛋白E、气道反应性,总免疫球蛋白E和气道反应性的相关性研究。方法选择有过敏性哮喘病史的患者,测定肺功能及舒张试验,阳性者采用UniCAP系统测定总免疫球蛋白E及特异性IgE,采用酶联免疫法测定体内维生素D主要的储存形式25羟维生素D3[25(OH)D3]含量,比较25(OH)D3水平和肺功能、总免疫球蛋白E、气道反应性的相关性以及总免疫球蛋白E和气道反应性相关性。结果哮喘患者血清25(OH)D3含量明显低于正常值(23.10±23.15),且男女之间差异无统计学意义;血清25(OH)D3与FEV1%pred呈明显正相关(r=0.428,P<0.01);和总免疫球蛋白E无明显相关性(r=-0.265,P>0.01);和气道反应性呈明显负相关(r=-0.559,P<0.01);总免疫球蛋白E和气道反应性呈明显正相关(r=0.578,P<0.01)。结论成人难治性过敏性哮喘患者血清25(OH)D3明显低于正常水平,对于总免疫球蛋白E虽然无明显影响,但明显影响着患者的肺功能及气道的反应性。

Objective This study measured the vitamin D levels in patients with allergic asthma and compared the results with the general population.To determine the relationship between serum concentrations of vitamin D and pulmonary function,TIgE,and airway responsivenss,the relationship between TIgE and airway responsivenss.Methods Vitamin D and TIgE levels were assessed in 41 patients with allergic asthma.There was no control group,and the study results were compared with the standard value.At the same time,lung function,airway hyperresponsiveness(AHR) were performed.Comparison the correlation of vitamin D and TIgE,pulmonary function and airway responsivenss,the relationship between TIgE and airway responsivenss.Results The prevalence of severe vitamin D3(23.10±23.15) deficiency was significantly in patients with allergic asthma than the standard value.vitamin D3 level were positive correlated with FEV1(r=0.428,P<0.01).There was no correlation on vitamin D level and TIgE(r=-0.265,P>0.01) and negtive correlated with AHR(r=-0.559,P<0.01).Here was negtive correlated with TIgE and AHR(r=0.578,P<0.01).Conclusions Vitamin D deficiency was highly prevalent in asthma patients,and vitamin D status was associated with lung function,AHR.Unlike the childen,there was no correlation on vitamin D level and TIgE in adult.