摘要
NOD样受体(NLRs)是细胞内感应器,能对各种不同的病原体和细胞内危险信号作出应答,从而诱导固有免疫反应。NLRC5是该家族成员之一,目前已经证实NLRC5是核转录因子κB、Ⅰ型干扰素、炎性体信号路径及MHC-Ⅰ基因表达的重要调节器,在固有免疫反应和适应性免疫反应中发挥举足轻重的作用。本文就的相关研究作一综述。
Nod-like receptors(NLRs) are intracellular sensors that respond to a variety of pathogen and intracellular danger signals to induce innate immune responses.NLRC5,a number of NLRs family,has recently been identified to be an important regulator of nuclear factor-κB,typeⅠinterferon,inflammation signaling pathways,and the expression of MHC classⅠ genes.It plays a pivotal role in the innate immune responses and adaptive immune responses.This paper summarizes the latest researches about NLRC5.
出处
《中华哮喘杂志（电子版）》
CAS
2013年第4期34-38,共5页
Chinese Journal of Asthma(Electronic Version)
