mTORC2信号通路调节上皮细胞钠通道的研究进展

Research advance of mTORC2signaling pathway in regulation of epithelial sodium channel

哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是一种丝氨酸/苏氨酸蛋白激酶,属于磷脂酰肌醇激酶相关激酶蛋白质家族成员。mTOR进化上高度保守,可整合营养、能量及生长因子等多种细胞外信号,在细胞生长、增殖、凋亡及自噬等过程中发挥极为重要的作用。在生物体内,mTOR有2种多蛋白复合物:mTORC1和mTORC2,目前mTORC1信号通路与肿瘤的关系研究较多,而对mTORC2的研究相对较少,近年来有研究发现mTORC2信号通路参与了上皮细胞钠通道的调节作用。

Mammalian target of rapamycin(mTOR),a serine /threoine protein kinase,is a member of phosphatidy-linositol kinase-related kinase family.It is highly conserved in evolution,which can integrate diverse extracelluar signals,such as nutrients,energy,and growth factors.mTOR plays a critical role in the processes of cell growth,proliferation,apoptosis,and autophagy.In vivo,mTOR forms two distinct multiprotein complexes:mTORC1 and mTORC2.By far,the researches about the relationship between mTORC1 signaling pathway and tumors have been attached greater importance to than mTORC2 signaling pathway.In recent years,several studies found that mTORC2 signaling pathway is involed in the regulation of epithelial sodium channel.