序贯放化疗与放化同步治疗中老年局部晚期非小细胞肺癌疗效及安全性的比较

Comparative analysis of therapeutic effect and security of locally advanced non-small cell lung cancer in the elderly by sequential and concurrent chemoradiotherapy

目的探讨序贯放化疗与放化同步治疗老年非小细胞肺癌的疗效以及安全性情况。方法收集2007年12月至2012年11月来我院就诊的老年非小细胞肺癌158例,随机分为A、B组,A组采用序贯放化疗法进行治疗,B组采用放化同步法进行治疗,观察2组的疗效以及不良反应的发生情况。结果治疗结束后,A组的总有效率为44.30%,B组的总有效率为66.67%,2组比较有显著性差异(P<0.05);而在恶心呕吐、白细胞和血小板减少等不良反应的发生率以及发作强度等方面A组显著低于B组(P<0.05)。结论序贯放化疗法的治疗效果虽然不及放化同步法好,但是其不良反应发生率小,更加适合于因身体素质不佳而不能耐受放化同步法治疗的老年非小细胞肺癌的治疗。

Objective To study the therapeutic effect and security of locally advanced non-small cell lung cancer in the elderly by sequential and concurrent chemoradiotherapy. Methods 158 elderly patients with non-small cell lung cancer from December 2007 to November 2012 who received the treatment in our hospital, were observed. Patients were divided into two groups (A and B) randomly. Group A were treated with sequential therapy, and group B were treated with concurrent therapy. After the treatment, the efficacy of the two groups as well as the occurrence of adverse reactions were analyzed. Results After the treatment, the effective rate of group A was 44.30%, compared with 66.67% in group B(P<0.05). On the other hand, group A had less adverse reaction rate of the treatment such as nausea, vomiting, neutropenia and thrombocytopenia than group B (P<0.05). Conclusions The concurrent chemoradiotherapy has a better effect than the sequential therapy in treating stage Ⅲ non-small cell lung cancer, but the sequential chemoradiotherapy has better security, so it is more suitable for elderly patients.