急性ST段抬高心肌梗死患者入院静息心率与心血管危险因素的关系

The relationship between admission heart rate and cardiovascular risk factors in subjects with acute myocardial infarction

目的 本研究旨在探讨中国人群中急性ST段抬高心肌梗死患者入院静息心率与心血管疾病危险因素的关系。方法 本研究共入选1234例急性ST段抬高心肌梗死患者。患者的实验室检测包括:静息心率,血压,血脂,血糖,尿素氮,肌酐,白细胞和亚型计数等情况。结果 Spearman相关分析显示,入院静息心率与血中尿素氮、肌酐、收缩压、舒张压、空腹血糖、白细胞计数、中性粒细胞计数及嗜酸性粒细胞计数呈显著正相关(P<0.05或P<0.01)。多元线性回归分析显示,中性粒细胞计数、舒张压、尿素氮与入院静息心率呈显著的独立相关(P<0.01)。结论 急性ST段抬高心肌梗死患者入院静息心率与血浆尿素氮、舒张压、中性粒细胞计数呈正相关,人体内交感神经活性可能是解释这种关系的一种通常因素。

Objective To explore the association of admission resting heart rate with the cardiovascular risk factors in Chinese subjects with acute ST elevation myocardial infarction.Methods A total of 1234 patients with acute ST elevation myocardial infarction were enrolled in the study.The patients' laboratory measurements including resting heart rate,blood pressure,blood lipid,blood glucose,blood urea nitrogen,creatinine,leukocyte and subtype count were performed.Results The Spearman correlation analysis indicated that the admission resting heart rate was significantly positively associated with blood urea nitrogen,creatinine,systolic blood pressure,diastolic blood pressure,fasting blood glucose,leukocyte count(109/L),neutrophil count(109/L),and eosinophil count(109/L)(P<0.05 or P<0.01) respectively.The multiple linear regression analysis suggested that neutrophil count(109/L),DBP,and blood urea nitrogen were significantly independently associated with the admission resting heart rate(P<0.01).Conclusions The admission resting heart rate is positively associated with neutrophil count,DBP,and blood urea nitrogen in patients with acute ST elevation myocardial infarction,and sympathetic activation might be a common factor explaining such an association.