复发性脑梗死患者血浆抗凝血酶Ⅲ活性、D-二聚体和纤维蛋白原检测的临床意义

Clinical significance of the levels of plasma antithrombin Ⅲ,D-Dimer and fibrinogen in patients with recurrent cerebral infarction

目的探讨检测抗凝血酶Ⅲ(ATⅢ)、D-二聚体(D-D)和纤维蛋白原(FIB)水平在复发性脑梗死中的临床意义。方法选取73例复发性脑梗死患者,104例初发脑梗死患者和86例正常老年人作为研究对象,检测其血浆中ATⅢ活性、D-D和FIB的水平。结果与正常对照组相比,初发脑梗死组和复发性脑梗死组血浆ATⅢ活性显著降低(P<0.05),血浆D-D、FIB水平明显升高(P<0.05);与初发脑梗死组相比,复发性脑梗死组血浆ATⅢ活性显著降低(P<0.05),血浆D-D、FIB水平明显升高(P<0.05)。结论检测血浆ATⅢ、D-D和FIB对脑梗死的早期诊断、预测脑梗死复发具有重要的临床意义。

Objective To study the clinical significance of the levels of plasma antithrombinⅢ(ATⅢ),D-Dimer(D-D) and fibrinogen(FIB) in patients with recurrent cerebral infarction.Methods The plasma samples of 73 patients with recurrent cerebral infarction,104 patients with first-time cerebral infarction were collected,and the levels of ATⅢ,D-D and FIB were detected and compared with 86 healthy subjects.Results Compared with controls,the activity of ATⅢ was lower and the levels of D-D and FIB were significantly higer in first-time cerebral infarction group and recurrent cerebral infarction group(all P<0.05).Compared with first-time cerebral infarction group,the activity of ATⅢ was lower and the levels of D-D and FIB were significantly higer in recurrent cerebral infarction group(all P<0.05).Conclusions Detecting the levels of plasma ATⅢ,D-D and FIB has an important clinical significance in early diagnosing cerebral infarction and predicting the recurrence of cerebral infarction.