视黄醇结合蛋白-4与初诊2型糖尿病患者血脂异常的相关性

Relationship of retinol binding protein 4 with hyperlipidemia in the patients with newly-diagnosed type 2 diabetes

目的探讨初诊2型糖尿病(T2DM)合并高脂血症的代谢特点及其与视黄醇结合蛋-4(RBP-4)的相关性。方法收集2010年1月至2012年3月初诊的T2DM患者131例,根据是否合并高脂血症〔高三酰甘油血症和(或)高总胆固醇血症]分为2组进行病例对照研究,其中T2DM不伴高脂血症组73例,T2DM伴高脂血症组58例。比较2组病人一般临床资料和生化指标等有无差异,并对相关指标做logistic回归分析。结果初诊T2DM合并高脂血症组患者年龄明显低于未合并高脂血症组(P<0.05),尿酸、RBP-4明显高于未合并高脂血症组(P<0.05),而体质量指数(BMI)、空腹血糖、糖化血红蛋白(HbA1c)在2组间无统计学意义。logistic回归分析发现RBP-4是初发T2DM合并高脂血症的独立危险因素。结论初诊T2DM合并高脂血症者较未合并高脂血症患者存在高尿酸血症相伴发生的风险;RBP-4在预测初发T2DM合并高脂血症风险方面有重要临床价值。

Objective To investigate the metabolic characteristics of newly-diagnosed type 2 diabetes with hyperlipoidemia and the risk factors. Methods A case-control study containing 131 case of newly-diagnosed type 2 diabetes was conducted from January 2010 to March 2012. The patients were divided into two groups according to with or without hyperlipoidemia, 73 patients without hyperlipoidemia and 58 patients with hyperlipoidemia. The blood pressure, body mass index (BMI) and biochemical indicators were compared between the two groups and logistic regresstion analysis was performed to investigate the risk factors. Results The age in hyperlipidemia group was significantly lower than that of the non-hyperlipidemia group. Uric acid and retinol binding protein 4 (RBP-4) were significantly higher than those of the non-hyperlipidemia group (P<0.05) . BMI, fasting plasma glucose, HbA1c showed no statistical difference between 2 groups (P>0.05). Logistic regression analysis revealed that RBP-4 was an independent risk factor for hyperlipidemia in the patients with type 2 diabetes. Conclusions The data suggest that the patients with newly-diagnosed type 2 diabetes complicated with hyperlipidemia are likely to suffer from hyperuricemia. RBP-4 may be an potential indicator of hyperlipidemia in the patients with newly-diagnosed type 2 diabetes.