伴发代谢综合征的老年精神分裂症认知功能研究

Study on cognitive function in senile schizophrenia disorders complicated with metabolic syndrome

目的探讨老年精神分裂症伴发代谢综合征(metabolic syndrome,MS)的认知功能状况及事件相关电位P300特征。方法选择符合《中国精神障碍分类与诊断标准》第3版(CCMD-3)精神分裂症诊断标准的老年患者(≥55岁)90例,其中伴发MS的患者45例(MS组),无MS患者45例(无MS组),予事件相关电位P300(P300)和蒙特利尔认知评估量表(Montreal cognitive assessment,MOCA)评价认知功能。结果 MS组PZ点N1,CZ、PZ点P2及FZ、CZ、PZ、OZ点N2、P3潜伏期较无MS组延长(P<0.05或0.01);MS组各点N2、P3波幅较无MS组降低(P<0.05或0.01);MS组MOCA量表的注意、抽象思维、记忆延迟因子分及总分低于无MS组(P<0.05或0.01)。结论伴有MS老年精神分裂症患者的认知功能损害更严重。

Objective To investigate the characteristics of cognitive function in senile schizophrenia disorders complicated with metabolic syndrome(MS) with event-related potential P300. Methods Ninety patients with senile schizophrenia disorders complicated with(MS) diagnosed according to CCMD-3 were recruited as research group. They were divided into MS group(n=45) and non-metabolic syndrome group(NMS group)(n=45). Cognitive function was evaluated with P300 and MOCA, and was compared between MS group and NMS group. Results P300 latencies of PZsite N1and CZ,PZ site P2 and FZ,CZ,PZ,OZsite N2,P3 prolonged in MS group compared with NMS group(P<0.05 or P<0.01);P300 amplitudes of FZ,CZ,PZ,OZ site N2,P3 shortened in MS group compared with NMS group(P<0.05 or P<0.01). Total score, attention score, Abstract thinking score and delay memory score of MOCA were significantly lower in MS group than those in NMS group(P<0.05 or P<0.01). Conclusions The senile schizophrenia disorders complicated with MS may have more obvious cognitive disorders.