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急性心肌梗死患者外周血单个核细胞趋化因子受体2基因表达及临床意义

Study on gene expression of CCR2 in the peripheral blood mononuclear cells of patients with acute myocardial infarction and its clinical significance
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摘要 目的研究急性心肌梗死(acute myocardial infarction,AMI)患者外周血单个核细胞趋化因子受体2(chemokine receptor 2,CCR2)基因表达及其与疾病发生、发展的关系。方法分别采用半定量逆转录-聚合酶链反应(RT-PCR)和Western blot检测32例AMI患者和21例健康者CCR2 mRNA和蛋白表达。结果 AMI患者外周血单个核细胞中CCR2基因mRNA和蛋白表达均明显高于健康者(P<0.05)。结论 CCR2基因表达与AMI发生存在一定相关性,在AMI的发病过程中起重要作用,为研究AMI的发病机制和预防提供了新依据。 Objective To investigate the role of chemokine receptor 2(CCR2) in the occurrence and development of acute myocardial infarction(AMI) . Methods Peripheral blood mononuclear cells(PBMC) were isolated from 32 patients with AMI and 21 healthy controls,and the expression level of CCR2 was detected by semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR) and western blot at mRNA and protein level respectively. Results The expression level of CCR2 was increased significantly in the patients with AMI (P < 0. 05) . Conclusions CCR2 may play an important role in AMI and may be a potential prevention basis involved in the regulatory mechanisms in the development of AMI.
出处 《实用老年医学》 CAS 2013年第8期654-656,共3页 Practical Geriatrics
关键词 急性心肌梗死 趋化因子受体 趋化作用 外周血单个核细胞 acute myocardial infarction chemokine receptor 2 chemotaxis peripheral blood mononuclear cells
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