不同剂量舒芬太尼对大鼠麻醉及恢复的影响

Influence of different doses of sufentanil on anesthesia and recovery in rats

为了研究不同剂量腹腔注射舒芬太尼对大鼠麻醉及恢复的影响,将60只SD大鼠随机分为5组(S1～S5),分别腹腔注射舒芬太尼50、60、150、250和400μg/kg,记录大鼠的翻正反射消失时间,翻正反射恢复后共济失调期和握杆时间,评估其麻醉深度。统计学分析显示大鼠翻正反射消失率S1为83.3%,S2至S5均为100%。随着舒芬太尼剂量的增加,翻正反射消失诱导期缩短,麻醉深度增加,翻正反射消失持续时间和翻正反射恢复后共济失调期延长,握杆时间减少。研究表明舒芬太尼腹腔给药对大鼠的麻醉及复苏的影响呈剂量依赖性,在60～150μg/kg可获得良好的麻醉深度和麻醉恢复质量。

To compare the influence of different doses of sufentanil administrated intraperitoneally on anesthesia and recovery in rats,sixty adult SD rats are randomly divided into 5 groups(S1~S5).Rats in S1~S5 are given a single intraperitoneal injection of sufentanil 50,60,150,250 and 400 μg/kg body weight respectively.The loss of righting reflex(LRR),the duration of post-LRR ataxia and the grip time in the duration of the post-LRR ataxia are recorded,and the anesthesia depth is assessed.The data of statistics analysis show that LRR rate in S2~S5 are 100%,whereas in S1 is 83.3%.With the increase of dose administrated,the time for induction of LRR decreased,the depth of anesthesia increased,the duration of LRR and post-LRR ataxia are prolonged and the time of grip is reduced.The results demonstrate that the effect of sufentanil administrated intraperitoneally on anesthesia and recovery in rats presents dose-dependence,and sufentanil in the dose of 60~150 μg/kg provides optimal depth of anesthesia and recovery quality.