气道重叠综合征研究新进展

Research of airway overlap syndrome

慢性阻塞性肺疾病(chronic obstructive pulmonary diseases,COPD)、支气管哮喘、阻塞性睡眠呼吸暂停低通气综合征(obstructivesleep apnea hypopnea syndrome,OSAHS)三者虽然是不同的疾病,有着各自的定义、病因病机、临床特征与治疗指南,但它们同属气道阻塞性疾病,尽管三者气道阻塞的部位不同。临床研究显示它们在流行病学、气道炎症与重塑、临床表现、治疗等方面出现两两或三者重叠现象,它们不是简单的叠加,而是成为一种疾病状态,这使临床医师在诊断、治疗上出现困惑。因此,我们参考了国内外最新研究文献,对此作一综述,并提出"气道重叠综合征"的概念,以供临床参考。

Chronic obstructive pulmonary disease , bronchial asthma and obstructive sleep apnea hypopnea syndrom are different diseases and have their own definition , etiology and pathogenesis , clinical features and treatment guidelines.They belong to the same airway obstructive disease , although the three have different parts of airway obstruction.Clinical studies have shown that they have overlapping phenomenon in epidemiology , airway inflammation and remodeling , clinical manifestation , treatment and so on in two or three.It is not a simple superposition , but become a state of conditions that confused the clinical doctors on diagnosis and treatment.Therefore , we refer to the latest research literature at home and abroad for the review , and put forward the concept of ' airway overlap syndrome ' for clinical reference.