结直肠癌患者血清中血管内皮生长因子的水平及其意义

Serum Vascular Endothelial Growth Factor Levels in Patients with Primary Colorectal Carcinoma and its Significance

目的:测定结直肠癌患者血清血管内皮生长因子(VEGF)的含量,分析其与临床病理指标间的关系。方法:采用ELISA法测定42例初治结直肠癌患者血清VEGF含量,正常对照30例。结果:结直肠癌患者血清VEGF浓度为274.21±218.38 pg/ml,明显高于正常对照组浓度(169.06±68.01 pg/ml,P<0.02),结肠癌患者血清VEGF浓度为346.52±168.57 pg/ml明显高于直肠癌患者(237.31±124.10 pg/ml,P<0.05)。Dukes B、C、D期组患者血清VEGF浓度与对照组相比均有明显差异(P<0.05),Dukes D期组与Dukes A、B、C期组亦均有明显差异(P<0.05)。结直肠癌患者血清VEGF浓度与年龄、性别无相关性(P>0.05)。结论:VEGF与结直肠癌的发生发展及癌肿部位有关,对探讨结直肠癌的发生机制,病情判断,预后及指导治疗有一定价值,对早期诊断似无帮助。

Objective:To detemine the correlation between serum vascular endothelial growth factor (VEGF) and clinical pathologic features in pre-treated patients with coloreetal carcinoma, Methods:Serum VEGF was measured by Enzyme-linked immunosorbent assay (ELJSA) in 30 healthy controls and 42 pretreated patients with coloreetal carcinoma. Results: Serum VEGF was significantly elevated in patients with primary coloreetal carcinoma in contrast to controls. Patients with the primary tumour localized in the colon had significantly ( P < 0.05) higher levels of VEGF than patients with the primary tumour localized in the rectum. Patients with Dukes stage B, C and D disease had significantly ( P < 0.05) higher levels of VEGF than controls. Patients with Dukes stage D disease had significantly ( P < 0.05) higher values than patients with Dukes stage A, B and C .There were no significant correlation among gender, age with serum VEGF ( P > 0.05). Conclusion: Serum VEGF was associated with the development, metostasis and location of coloreetal carcinoma. It can be used as important references in the therapeutic effect and prognosis. It is not a useful marker for diagnosis of early coloreetal carcinoma.