小儿幽门螺杆菌感染与白细胞介素-8含量的关系

The Relationship Between Helicobacter Pylori Infection and Content of Interleukin-8 in Children.

目的:探讨小儿幽门螺杆菌(Hp)感染与胃黏膜及血清白细胞介素-8(IL-8)含量的关系。方法:对43例接受胃镜检查的患儿用双抗体夹心酶联免疫吸附法测定其胃黏膜培养上清及血清中IL-8的含量,并比较Hp感染与非Hp感染患儿胃黏膜及血清中IL-8含量的差异。结果:Hp感染患儿胃黏膜中IL-8含量显著高于非Hp感染患儿(P<O.001)。经根治Hp治疗后,Hp感染患儿胃黏膜中IL-8含量显著下降(P<0.001),而血清IL-8含量在Hp感染组与非Hp感染组无显著差异(P>0.05)。Hp感染组根治Hp治疗前后血清IL-8含量亦无显著变化(P>0.05)。结论:Hp感染可以诱导胃黏膜炎症细胞合成IL-8,IL-8在Hp相关性胃十二指肠疾病的发病机制中起着重要作用。

Objective:To explore the relationship between helicobacter pylori (Hp) infection in children and the level of interleukin-8(lL-8)in gastric mucosa and serum. Methods: ELISA was used to detect the level of IL-8 in supemate fluid of gsatromucosal tissue eulture and serum from 43 children who accepted endoscopy inspection, and compared between Hp infected and non-Hp infected children the level of IL-8. Results: The IL-8 content of gastric mucosa in Hp infected children was higher than non-Hp infected children ( P < 0.01) apparently. After eradicating Hp treatment, the IL-8 content in Hp infected children in gastric mucosa decreased apparently ( P < 0.01) , and serum IL-8 content in Hp infected group and non-Hp infected group was not differ-ent( P > 0.05). In serum, the IL-8 content in Hp infection group showed no distinct variation ( P > 0. 05) before and after Hp eradication. Conclusion : Hp infection can induce inflammatory cell to secrete IL-8. IL-8 plays an important role in the pathogenesis of Hp related gastrointestinal disease.