FIB和D-D检测对老年人下肢骨折术后并发深静脉血栓的临床意义

Clinical Significance of the Testing Serum Fibrinogen and d-dimer on the Postoperative Intercurrent Deep Vein Thrombosis for the Elder with Lower Limb Fractures

目的探讨纤维蛋白原(Fibrinogen,FIB)和D-二聚体(D-dimer,D-D)检测对老年人下肢骨折术后并发深静脉血栓(Deep Vein Thrombosis,DVT)的临床意义。方法对88例老年人下肢骨折患者(研究组)术前及术后第3 d进行血清FIB和D-D检测,并根据彩超结果分为DVT组10例和非DVT组78例;另选取同期体检健康者88例作为对照组,比较FIB和D-D水平。结果研究组中的FIB和D-D明显高于对照组(P<0.01);DVT组术后第3 d FIB和D-D均高于术前(P<0.05),非DVT组术前和术后第3 d对比FIB和D-D检测结果均无显著性差异(P>0.05);术前DVT组与非DVT组对比FIB和D-D检测结果均无显著性差异(P>0.05);术后第3 d DVT组FIB和D-D均明显高于非DVT组(P<0.05);DVT组FIB和D-D水平呈正相关,r=0.834,t=14.020,P<0.01。结论 FIB和D-D检测对老年人下肢骨折术后并发深静脉血栓的预防及治疗具有重要的临床意义。

Objective To discuss the clinical significance of the testing serum fibrinogen and d-dimer on the postoperative intercurrent deep vein thrombosis for the elder with lower limb fractures.Methods The serum FIB and D-D were tested in 88 cases of the elder with lower limb fractures(study group) in the preoperative time and on the postoperative third day,and the patients were divided into 10 cases in DVT group,and 78 cases in non-DVT group,according to the outcome of color doppler ultrasound.At the same time,88 medical examination cases of healthy people were in the control group,and the serum FIB and D-D levels were compared.Results The FIB and D-D levels were significantly higher in the study group than in the control group(P<0.01);The FIB and D-D levels of the DVT group on the postoperative third day were both higher than those in the preoperative time(P<0.05);The FIB and D-D levels of the non-DVT group had no significant difference between the preoperative time and the postoperative third day(P>0.05);The preoperative FIB and D-D levels of the DVT group and the non-DVT group had no significant difference(P>0.05);The FIB and D-D levels of the DVT group were significantly higher than those of the non-DVT group on the postoperative third day(P<0.05);The level of the DVT group plasma FIB was positively correlated with D-D,r=0.834,t=14.020,P<0.01.Conclusion The testing of the FIB and D-D has remarkable clinical significance on prevention and treatment of the postoperative intercurrent deep vein thrombosis for the elder with lower limb fractures.