数值化免疫便潜血试验对诊断大肠癌的临床价值研究

Value of Immunochemical Fecal Occult Blood Test (IFOBT) in Diagnosis of Colorectal Diseases

目的探讨数值化免疫便潜血试验对诊断大肠癌的临床意义。方法选择我院2008-01～2011-08间行数值化免疫便潜血检查及化学法便潜血检查病人共251例,并行大肠镜检查结合病理确诊。结果数值化免疫便潜血法和化学法对结直肠癌的阳性率分别为100%(57/57)和84.2%(48/57),P<0.05;大肠息肉分别为38.6%(32/83)和10.8%(9/83),P<0.05;炎症性肠病分别为100%(31/31)和80.6%(26/31),P>0.05;非特异性肠炎分别为86.8%(33/38)和73.7%(28/38),P>0.05。正常大肠者分别为2.38%(1/42)和19.0%(8/42),P<0.05。结论数值化免疫便潜血试验对诊断大肠癌和结肠息肉优于化学便潜血法,假阳性率明显降低。

Objective To discuss immunochemical fecal occult blood test(IFOBT) in diagnosis colorectal diseases.Methods 251 patients took immunochemical fecal occult blood test(IFOBT) and chromagraphy fecal occult blood tests(CFOBT).All the patients were were checked-up by colonoscopy.Results The positive rates of IFOBT and CFOBT in colorectal cancer group were 100.0%(57 /57) and 84.2%(48 /57)(P < 0.05);in colorectal polyp group were 38.6%(32 /83) and 10.8%(9 /83)(P < 0.05);in inflammatory bowel disease group were 100.0%(31 /31) and 80.6%(26 /31)(P > 0.05);in non-secific enteritis were 86.8%(33 /38) and 73.7%(28/38)(P >0.05);in normal group were 2.38%(1/42) and 19.0%(8/42)(P < 0.05).Conclusion The IFOBT is better than CFOBT in diagnosis of colorectal cancer and colonic polyps.The IFOBT has lower false positive rates.