联合应用托特罗定与坦洛新治疗女性膀胱过度活动症的临床疗效分析

Analysis of the Effect for the Female Overactive Blader by the Combination of Tolterodine and Tamsulosin Treatment

目的分析联合应用托特罗定与坦洛新治疗女性膀胱过度活动症的临床疗效。方法将80例膀胱过度活动症女性患者按就诊顺序随机分为A、B、C、D 4组,每组20例,A组给予口服安慰剂,B组给予单独口服托特罗定,C组给予单独口服坦洛新,D组给予联合口服托特罗定和坦洛新,治疗前和服药后4周分别测定各组最大尿流率(Qmax),并通过调查问卷的形式,记录各组储尿期分数、24 h排尿次数、平均夜尿次数、平均每天尿急次数、储尿期尿失禁次数、平均每次尿量及用药后不良反应。结果治疗4周后,A组较治疗前相比无明显差异(P>0.05);B组除尿流率较治疗前无差异(P>0.05)外,其余各项指标均有差异;C组除24 h排尿次数有差异外(P<0.05),其余各项指标均有显著性差异(P<0.001);D组各项指标均有显著性差异(P<0.001)。结论托特罗定联合坦洛新治疗女性膀胱过度活动症有着确切的临床疗效,效果优于单独应用托特罗定、坦洛新,不良反应发生率低,是一种安全、有效的治疗方案。

Objective To analyze the efficacy of the combination of tolterodine and tamsulosin treatment of women with overactive bladder.Methods 80 female overactive blodder patients according to treatment order were randomly divided into A,B,C,D four groups which had 20 patients in each.Group a was given by oral placebo,group B was given by a single oral tolterodine,group C was given by a single oral tamsulosin,then D group was given by combination of oral tolterodine with tamsulosin.Maximum flow rate(Qmax) were measured before treatment and medication after 4 weeks.A questionnaire recorded each group urine storage period scores,a 24-hour voiding frequency,average frequency of nocturia,the average daily number of incontinence episodes of urgency,frequency,urinary reservoir period,average per urine and drug adverse reactions.Results After 4 weeks of treatment,group A compared with pre-treatment had no significant difference(P > 0.05);group B had no difference(P > 0.05) in the treatment of urinary flow rate,and the rest of the indicators were different;C group in addition to the 24-hour voiding frequency differences(P < 0.05),and the rest of the indicators showed significant differences(P < 0.001);D group indicators were significantly different(P < 0.001).Conclusion Tolterodine joint tamsulosin treatment of women with overactive bladder exact clinical efficacy superior to tolterodine alone or tamsulosin,a low incidence of adverse reactions,is a safe and effective treatment program.