摘要
Objective To evaluate the prophylaxis and therapy of Isaria felina(IF) on glycerin-induced acute renal failure(ARF) in rats.Methods Forty male Wistar rats were divided into control,model,Uremic Clearance Granule(UCG,positive control),high-and low-dose IF groups.Rats in the high-and low-dose IF groups were ig administered with 200 and 100 mg/kg IF,respectively,while rats were ig administered with 3.6 g/kg UCG successively for 7 d to establish UCG group.The rats in model,control,and drug-treated groups were im injected with 8 mL/kg 50% glycerin after drinking was quitted for 24 h to induce ARF in rats.The drugs were continued to give thereafter.The level of blood urea nitrogen(BUN) and serum creatinine(SCr) were determined 24 and 72 h after the injection of glycerin,also the kidney was dissected for pathology examination.Results Im injection with 8 mL/kg 50% glycerin could successfully induce ARF in rats.The dose of 200 mg/kg IF could reduce the high levels of BUN and SCr,and ameliorate the pathological damage of the kidney.Conclusion IF has good protective and therapeutic effects on ARF and it is a potential and valuable Chinese herb for ARF.
Objective To evaluate the prophylaxis and therapy of Isaria felina(IF) on glycerin-induced acute renal failure(ARF) in rats.Methods Forty male Wistar rats were divided into control,model,Uremic Clearance Granule(UCG,positive control),high-and low-dose IF groups.Rats in the high-and low-dose IF groups were ig administered with 200 and 100 mg/kg IF,respectively,while rats were ig administered with 3.6 g/kg UCG successively for 7 d to establish UCG group.The rats in model,control,and drug-treated groups were im injected with 8 mL/kg 50% glycerin after drinking was quitted for 24 h to induce ARF in rats.The drugs were continued to give thereafter.The level of blood urea nitrogen(BUN) and serum creatinine(SCr) were determined 24 and 72 h after the injection of glycerin,also the kidney was dissected for pathology examination.Results Im injection with 8 mL/kg 50% glycerin could successfully induce ARF in rats.The dose of 200 mg/kg IF could reduce the high levels of BUN and SCr,and ameliorate the pathological damage of the kidney.Conclusion IF has good protective and therapeutic effects on ARF and it is a potential and valuable Chinese herb for ARF.
作者
YANG Xi-hua2,3,ZHANG Sheng-wan1,REN Lian-sheng3,BAI Xi-hua3 1.College of Life Science,Shanxi University,Taiyuan 030006,China 2.College of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China 3.Department of Comparative Medicine,Shanxi Cancer Institute,Taiyuan 030013,China
