尿微量清蛋白检测诊断糖尿病肾病临床分析

Clinical Analysis of Urine Microalbumin Detection and Diagnosis of Diabetic Nephropathy

目的探讨尿微量清蛋白(U-mAlb)检测在糖尿病肾病(DMN)早期诊断中的应用价值。方法抽选150例临床已确诊为2型糖尿病(DM)患者,并将其中75例已确诊为DMN的患者作为肾病组,75例仅诊断为2型糖尿病作为DM组,选取同期健康者75例作为正常对照组,比较3组患者血清肌酐(Scr)、尿素(Urea)以及尿U-mAlb各指标检测值及检测异常率的差异性。结果DM组和肾病组患者Scr、Urea以及U-mAlb检测值明显高于正常对照组(P<0.05),而肾病组各指标检测值又明显高于DM组(P<0.05);在定量异常方面:肾病组Scr、Urea以及U-mAlb定量异常率显著高于DM组和正常对照组,其中以U-mAlb定量异常率最高。结论尿微量清蛋白检测对于早期肾损伤灵敏度高于Scr、Urea,可以应用于临床对糖尿病肾病的早期诊断。

Objective To explore the value of urine microalbumin(U-mAlb) for the early diagnosis of diabetic nephropathy(DMN).Methods Selecting 150 cases of patients with clinical diagnosis of type 2 diabetes mellitus(DM).And 75 cases have been diagnosed in patients with DMN as nephropathy group,75 patients diagnosed with type 2 diabetes patients as DM group,and 75 healthy subjects as health group at the same time.Results DM and nephropathy patients,Scr,Urea and the U-mAlb detection value was significantly higher than the healthy group(P < 0.05),and the nephropathy group index detection was significantly higher than DM group(P < 0.05);From quantitative abnormalities aspects: nephropathy group Scr,Urea and the U-mAlb quantitative abnormal rate was significantly higher than DM group,among which U-mAlb quantitative abnormalities remained highest accuracy rate.Conclusion The urine microalbumin detection of early renal damage sensitivity is higher than Scr,Urea,and can be applied to clinical early diagnosis of diabetic nephropathy.