5种血清肿瘤标志物检测在肺癌诊断中的临床价值

Diagnostic value of five serum tumor markers in lung cancer

目的探讨5种血清肿瘤标志物:糖类抗原153(CA153)、糖类抗原125(CA125)、神经特异性烯醇化酶(NSE)、癌胚抗原(CEA)和细胞角蛋白21-1片段(CYFRA21-1)在肺癌诊断中的临床价值。方法采用免疫化学发光法分别检测62例肺癌患者、52例肺良性疾病患者和46例健康对照组血清中的5种肿瘤标志物含量,并对其敏感性、特异性及准确性进行分析,评价其诊断价值。结果肺癌患者5种标志物血清浓度明显高于健康对照组(P<0.001);除CA125外,其他4种含量均明显高于肺良性疾患组(P<0.01)。肺癌组5种标志物阳性检出率均明显高于肺良性疾患组和健康对照组(P<0.005)。肺鳞癌、肺腺癌和小细胞肺癌中阳性检出率最高的分别是CYFRA21-1(76.92%)、CEA(70.83%)和NSE(75%)。联合检测可明显提高肺癌诊断的敏感性(P<0.01)。结论联合检测肿瘤标志物在肺癌诊断及肺癌病理分型中具有较高的临床应用价值。

Objective To explore the diagnostic value of serum CA125,CA153,neuron-specific enolase(NSE),car-cinoembryonic antigen(CEA) and CYFRA21-1 in lung cancer.Methods Five serum tumor markers levels were de-tected by chemiluminescence immunoassay and samples came from 62 patients with lung cancer and 52 patients withbenign lung diseases patients and 46 normal adults.The diagnosis sensitivity and specificity were analyzed respective-ly.Results Serum tumor markers levels in lung cancer group were significantly higher than those in control group(P <0.001).Four serum tumor markers(except for CA125) levels in lung cancer group were significantly higher thanthose in benign lung diseases patients(P < 0.01).The positive ratio of five tumor markers were significantly higherthan those in benign lung diseases patients and normal adults(P < 0.005).CYFRA21-1,CEA and NSE appeared thehighest positive ratio in squamous cell carcinoma(76.92%),adenocarcinoma(70.83%) and small cell lung cancer(75.0%) respectively.Those tumor markers combined measurement may be more sensitive in lung cancer(P <0.01).Conclusion The combined determination of serum tumor markers could significantly improve the sensitivityand specificity in the diagnosis and classification of lung cancer.