摘要
目的探讨老年高血压患者血同型半胱氨酸(Hcy)与脉搏波传导速度的关系。方法将114例老年高血压患者按照血Hcy水平的高低分为2组:正常组61例,血Hcy≤15μmol/L;升高组53例,血Hcy>15μmol/L。分别测定2组患者的脉搏波传导速度、踝臂指数、空腹血糖、糖化血红蛋白、肌酐、尿酸、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、超敏C反应蛋白以及24 h平均血压。结果正常组和升高组的血Hcy水平分别为(11.71±1.88)μmol/L和(22.41±8.61)μmol/L(P<0.01),脉搏波传导速度分别为(1561±201)cm/s和(2150±476)cm/s(P<0.01),且升高组血肌酐水平明显高于正常组(P<0.05)。多元回归分析显示脉搏波传导速度与血Hcy水平有显著相关性(P<0.01)。结论老年高血压患者脉搏波传导速度的增快与高Hcy血症关系密切。
Objective To investigate the relationship between plasma homocysteine(Hcy) level and brachial-ankle pulse wave velocity(baPWV) in elderly patients with hypertension.Methods 114 elderly patients with hypertension were divided into 2 groups according to Hcy levels,normal-Hcy group(n = 61) with a level of Hcy≤15 μmol / L and highHcy group(n = 53) with a level of Hcy > 15 μmol / L.The levels of baPWV and ankle-brachial index(ABI) were assessed by an automatic oscillometric method.Fasting plasma glucose,creatinine,uric acid,triglyceride,total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol,hs-CRP and mean blood pressure were examined at the same time.Results The level of Hcy was significantly higher in the high-Hcy group(22.41 ± 8.61 μmol / L) than that in the normal-Hcy group(11.71 ± 1.88 μmol / L)(P<0.01).The level of baPWV was higher in the high-Hcy group(2150 ± 476 cm / s) than that in the normal-Hcy group(1561 ± 201 cm / s)(P<0.01).The level of creatinine was higher in the high-Hcy group than that in the normal-Hcy group(P<0.05).Multiple regression analysis showed that baPWV was independently predicted by Hcy level.Conclusions The elevated level of Hcy in elderly patients with hypertension is closely correlated with baPWV.
出处
《实用老年医学》
CAS
2013年第9期745-747,共3页
Practical Geriatrics