TS蛋白水平与培美曲塞治疗老年肺腺癌疗效的关系

Significance of thymidylate synthase protein expression in senile patients with pulmonary adenocarcinoma treated with pemetrexed

目的探讨老年肺腺癌胸腺核苷酸(TS)蛋白表达水平与培美曲塞疗效间的关系。方法 29例老年晚期肺腺癌患者以Western Blot检测肿瘤组织中TS蛋白含量,同时接受培美曲塞联合卡铂方案化疗,分析TS蛋白水平与疾病控制率、疾病缓解时间(PFS)和生存时间(OS)间的关系。结果 29例患者中位疾病进展期为3.8月,中位生存期为17.6月。其中TS低表达者(≤8.43)较高表达者(>8.43)的中位疾病进展期和中位生存期均明显延长(PFS:4.8月比2.6月,P<0.05;OS:25.8月比11.7月,P<0.05)。结论老年肺腺癌患者TS蛋白表达水平与培美曲塞治疗的疗效相关。

Objective To evaluate the relationship between TS expression and the efficacy of pemetrexed in senile patients with pulmonary adenocarcinoma. Methods Twenty-nine senile advanced pulmonary adenocarcinoma patients, whose TS expression in tumor tissues was examined by Western Blot,were treated with pemetrexed plus carboplatin. The association between treatment response,survival and TS expression was evaluated. Results The median progression free survival( PFS) of 29 patients was 3. 8 months,and the median overall survival( OS) was 17. 6 months. Patients with low TS expression( ≤8. 43) had a longer median PFS and a longer median OS compared with patients with high TS expression( > 8. 43)( PFS,4. 8 vs. 2. 6 months,P < 0. 05; OS,25. 8 vs. 11. 7 months,P < 0. 05). Conclusions The expression of TS protein in pulmonary adenocarcinoma biopsy is associated with the sensitivity of patients to pemetrexed.