动脉粥样硬化患者检测同型半胱氨酸的临床意义

Clinical Significance of Testing Homocysteine for Atherosclerotic

目的研究血清同型半胱氨酸(HCY)在冠状动脉粥样硬化性心脏病(CHD)患者不同临床类型中的浓度,探讨HCY与CHD的关系。方法利用循环酶法(Enzymatic Cycling Method)检测CHD患者(42例)和健康体检者对照组(20例)血清中HCY的水平。结果 CHD组HCY的含量明显高于对照组(P<0.05),急性心肌梗死患者(AMI)HCY含量>不稳定性心绞痛者(UAP)>稳定性心绞痛者(SAP),传统危险因素与无危险因素患者之间HCY的含量均无统计学意义(均P>0.05),且HCY水平不受性别年龄因素影响。结论高HCY水平是CHD的独立危险因素,病情越重,HCY的含量越高。HCY与CHD病变的发生、发展可能直接相关。检测HCY水平对预防和减低CHD的发生具有重要意义。

Objective To debate the relationship between severity of homocysteine( HCY) and coronary atherosclerotic heart disease( CHD) patients as well as their different clinical types. Methods Serum HCY level of 42 cases with CHD in observation group and 20 cases in control group were detected by enzymatic cycling method. Results CHD group had high concentration of Hcy than control group( P< 0. 01). So did the Hcy in patients with AMD than patients with UAP,as well as patients with UAP than patients with SAP( P < 0. 01).There was no statistic significance between two groups with or without risk factors( P > 0. 05). Conclusion HCY is an independent risk factor for CHD. The more serious of the condition is,the higher of Hcy levels are. HCY may have direct relationship with the genesis and development of CHD. Detecting the Hcy level will have great significance in preventing and reducing the occurrence of CHD.